Osteomyelitis is a hypoxic condition as shown by intramdullary po2 measurements, which ususally give values below 30mmhg.

Mechanisms of action of Hyperbaric Oxygent - HBO:

HBO can raise the tissue oxygen tension in partially ischemic hypoxic tissues by providing adequate oxygen, leukocyte killing mechanisms are enhanced. Optimal wound po2 can enhance osteogenesis or neovascularization. Improved vascularity facilitaes entry of leukocytes, antibodies and antibiotics to the infected area.

The effectiveness of Hyperbaric Oxygen Treatments (HBOT) in osteomyelits is a result of the toxic effect to the microorganisms due to the increased levels of oxygen